Identification of a Novel P190-Derived Breakpoint Peptide Suitable for Peptide Vaccine Therapeutic Approach in Ph+ Acute Lymphoblastic Leukemia Patients

• Published in: Leukemia Research and Treatment Vol. 2012; no. 2012; pp. 38 - 41
• Main Authors: Raspadori, Donatella, Lauria, Francesco, Bocchia, Monica, Ippoliti, Micaela, Gozzetti, Alessandro, Pietrini, Alice, Aprile, Lara, Defina, Marzia, Gozzini, Antonella, Baratè, Claudia
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2012; Hindawi Puplishing Corporation; Hindawi Publishing Corporation

Ph+ acute lymphoblastic leukemia (Ph+ ALL) is a high-risk acute leukemia with poor prognosis, in which the specific t(9;22)(q34;q11) translocation results in a chimeric bcr-abl (e1a2 breakpoint) and in a 190 KD protein (p190) with constitutive tyrosine kinase activity. The advent of first- and secon...