Swelling Behavior and Controlled Release of Theophylline and Sulfamethoxazole Drugs in β-Lactoglobulin Protein Gels Obtained by Phase Separation in Water/Ethanol Mixture

• Published in: Biomacromolecules Vol. 7; no. 1; pp. 323 - 330
• Main Authors: Reddy, Thimma T, Lavenant, Laurence, Lefebvre, Jacques, Renard, Denis
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.01.2006
• Subjects: Applied sciences; Biological and medical sciences; Chemical and Process Engineering; Engineering Sciences; Ethanol - chemistry; Exact sciences and technology; Food engineering; Gels - chemistry; General pharmacology; Kinetics; Lactoglobulins - chemistry; Life Sciences; Medical sciences; Natural polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Phase Transition; Physicochemistry of polymers; Proteins; Solubility; Solvents - chemistry; Sulfamethoxazole - chemistry; Theophylline - chemistry; Water - chemistry; Solvent effect; Swelling; Control release polymer; β-Lactoglobulin; Physical gel; Drug carrier; Antiasthma agent; Experimental study; In vitro; Protein; Sulfamethoxazole; Medium effect; Antiinfectious; Kinetics; Hydrogel; Release; Theophylline; DRUG; SWELLING; LACTOGLOGULINE BETA; LIBERATION CONTROLEE; BETA LACTOGLOBULIN; CONTROLLED RELEASE; GELATION

Physically cross-linked β-lactoglobulin (BLG) protein gels containing theophylline and sulfamethoxazole low molecular weight drugs were prepared in 50% ethanol solution at pH 8 and two protein concentrations (6 and 7% (w/v)). Swelling behavior of cylindrical gels showed that, irrespective of the hyd...