Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing

• Published in: ACS applied materials & interfaces Vol. 14; no. 47; pp. 52643 - 52658
• Main Authors: Ni, Zhipeng, Yu, Haojie, Wang, Li, Huang, Yudi, Lu, Hui, Zhou, Haiying, Liu, Qingxian
• Format: Journal Article
• Language: English
• Published: American Chemical Society 30.11.2022
• Subjects: Biological and Medical Applications of Materials and Interfaces; prodrug; diabetic wound; anti-inflammation; ROS-responsive; polyphosphazene

The high level of reactive oxygen species (ROS) and bacterial infection impede wound healing of the diabetic wound. Here, benefiting from the antioxidation effects of tannic acid (TA) and ROS-responsive phenylborate ester (PBAE), a series of ROS-responsive anti-inflammatory TA-conjugated nanoparticl...