Phase I trial comparing bile acid and short-chain fatty acid alterations in stool collected from human subjects treated with omadacycline or vancomycin - Jo, Jinhee; Hu, Chenlin; Horvath, Thomas D.; Haidacher, Sigmund J.; Begum, Khurshida; Alam, M. Jahangir; Garey, Kevin W. (Antimicrobial agents and chemotherapy, 2025)
Keywords: Adult; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Antimicrobial Chemotherapy; Bile Acids and Salts - metabolism; Clostridioides difficile - drug effects; Clostridioides difficile - metabolism; Fatty Acids, Volatile - metabolism; Feces - chemistry; Feces - microbiology; Female; Healthy Volunteers; Humans; Male; Mechanisms of Action: Physiological Effects; Middle Aged; Tandem Mass Spectrometry; Tetracyclines - administration & dosage; Tetracyclines - adverse effects; Vancomycin - administration & dosage; Vancomycin - adverse effects; Young Adult; Clostridioides difficile; human subjects; short-chain fatty acids; bile acids