Ipsilateral or contralateral boosting of mice with mRNA vaccines confers equivalent immunity and protection against a SARS-CoV-2 Omicron strain

• Published in: Journal of virology Vol. 98; no. 9; p. e0057424
• Main Authors: Ying, Baoling, Liang, Chieh-Yu, Desai, Pritesh, Scheaffer, Suzanne M, Elbashir, Sayda M, Edwards, Darin K, Thackray, Larissa B, Diamond, Michael S
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 28.08.2024
• Subjects: Editor’s Pick; Vaccines and Antiviral Agents; Virology; SARS-CoV-2; infection; vaccine; immunity; B-cell responses; T cell responses

Boosting with mRNA vaccines encoding variant-matched spike proteins has been implemented to mitigate their reduced efficacy against emerging SARS-CoV-2 variants. Nonetheless, in humans, it remains unclear whether boosting in the ipsilateral or contralateral arm with respect to the priming doses impa...