Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood–Spinal Cord Barrier Repair after Spinal Cord Injury

• Published in: ACS nano Vol. 17; no. 18; pp. 18008 - 18024
• Main Authors: Xie, Yong, Sun, Yi, Liu, Yudong, Zhao, Jinyun, Liu, Quanbo, Xu, Jiaqi, Qin, Yiming, He, Rundong, Yuan, Feifei, Wu, Tianding, Duan, Chunyue, Jiang, Liyuan, Lu, Hongbin, Hu, Jianzhong
• Format: Journal Article
• Language: English
• Published: American Chemical Society 26.09.2023
• Subjects: Nerve Growth Factor Receptor; Umbilical Cord Mesenchymal Stem Cell; Melanoma Cell Adhesion Molecule; Blood−Spinal Cord Barrier; Exosome; Spinal Cord Injury

Spinal cord injury (SCI) disrupts the blood–spinal cord barrier (BSCB), potentially exacerbating nerve damage and emphasizing the criticality of preserving the BSCB integrity during SCI treatment. This study explores an alternative therapeutic approach for SCI by identifying a subpopulation of exoso...