3D-Printed Silk Fibroin Mesh with Guidance of Directional Cell Growth for Treating Pelvic Organ Prolapse

• Published in: ACS biomaterials science & engineering Vol. 11; no. 4; pp. 2367 - 2377
• Main Authors: Zheng, Zili, Wang, Min, Ren, An, Cheng, Zhangyuan, Li, Xiangjuan, Guo, Chengchen
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14.04.2025
• Subjects: Animals; Biocompatible Materials - chemistry; Cell Proliferation - drug effects; Female; Fibroins - chemistry; Humans; Pelvic Organ Prolapse - surgery; Pelvic Organ Prolapse - therapy; Printing, Three-Dimensional; Surgical Mesh; Tensile Strength; Tissue Engineering and Regenerative Medicine; silk; tissue integration; biocompatibility; pelvic organ prolapse; 3D printing; mesh

Damages to the supportive structure of the pelvic floor frequently result in pelvic organ prolapse (POP), which diminishes the quality of life. Surgical repair typically involves mesh implantation to reinforce the weakened tissues. However, the commonly used polypropylene (PP) mesh can lead to sever...