A Novel 7H‑[1,2,4]Triazolo[3,4‑b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis

• Published in: ACS medicinal chemistry letters Vol. 14; no. 10; pp. 1338 - 1343
• Main Authors: Rab, Andras, Yang, Xun, Tracy, William F., Hong, Jeong S., Joshi, Disha, Manfredi, Candela, Ponnaluri, Sadhana S., Kolykhalov, Alexander A., Qui, Min, Fu, Haian, Du, Yuhong, Davies, Huw M. L., Sorscher, Eric J.
• Format: Journal Article
• Language: English
• Published: American Chemical Society 12.10.2023
• Subjects: Letter; high throughput compound library screening; drug discovery; cystic fibrosis; CFTR

Cystic fibrosis (CF) is an autosomal genetic disorder caused by disrupted anion transport in epithelial cells lining tissues in the human airways and digestive system. While cystic fibrosis transmembrane conductance regulator (CFTR) modulator compounds have provided transformative improvement in CF...