Comprehensive Two-Dimensional Hydrophilic Interaction Chromatography (HILIC) × Reversed-Phase Liquid Chromatography Coupled to High-Resolution Mass Spectrometry (RP-LC-UV-MS) Analysis of Anthocyanins and Derived Pigments in Red Wine

Changes in anthocyanin chemistry represent some of the most important transformations involved in red wine aging. However, accurate analysis of the derived pigments, as required to study the evolution of anthocyanins and tannins during aging, is hampered by their extreme structural diversity, low le...

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Published inAnalytical chemistry (Washington) Vol. 87; no. 24; pp. 12006 - 12015
Main Authors Willemse, Chandré M, Stander, Maria A, Vestner, Jochen, Tredoux, Andreas G. J, de Villiers, André
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 15.12.2015
Subjects
Anthocyanins - analysis
Chromatography, Liquid
Chromatography, Reverse-Phase
Food Analysis - methods
Hydrophobic and Hydrophilic Interactions
Life Sciences
Mass Spectrometry
Pigments, Biological - analysis
Wine - analysis
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Abstract Changes in anthocyanin chemistry represent some of the most important transformations involved in red wine aging. However, accurate analysis of the derived pigments, as required to study the evolution of anthocyanins and tannins during aging, is hampered by their extreme structural diversity, low levels, and the fact that many of these compounds have identical mass spectral characteristics. In this context, chromatographic separation is critical. In this contribution, the application of online hydrophilic interaction chromatography (HILIC) × reversed-phase liquid chromatography (RP-LC) separation coupled to high-resolution mass spectrometry (MS) is described for the detailed characterization of anthocyanins and their derived pigments in aged red wine. A systematic approach was followed for the optimization of HILIC × RP-LC separation parameters using a capillary liquid chromatography (LC) system in the first dimension and an ultrahigh-pressure LC system in the second dimension to ensure maximum sensitivity and performance. Ninety four (94) anthocyanin-derived pigments were tentatively identified in one- and six-year-old Pinotage wines using accurate mass and fragmentation information obtained using quadrupole-time-of-flight mass spectrometry (Q-TOF-MS). Online HILIC × RP-LC-MS was found to offer high-resolution separation, because of the combination of two different separation modes, while the structured elution order observed improved the certainty in compound identification. Therefore, this approach shows promise for the detailed elucidation of the chemical alteration of anthocyanins during wine aging.
AbstractList Changes in anthocyanin chemistry represent some of the most important transformations involved in red wine aging. However, accurate analysis of the derived pigments, as required to study the evolution of anthocyanins and tannins during aging, is hampered by their extreme structural diversity, low levels, and the fact that many of these compounds have identical mass spectral characteristics. In this context, chromatographic separation is critical. In this contribution, the application of online hydrophilic interaction chromatography (HILIC) x reversed-phase liquid chromatography (RP-LC) separation coupled to high-resolution mass spectrometry (MS) is described for the detailed characterization of anthocyanins and their derived pigments in aged red wine. A systematic approach was followed for the optimization of HILIC x RP-LC separation parameters using a capillary liquid chromatography (LC) system in the first dimension and an ultrahigh-pressure LC system in the second dimension to ensure maximum sensitivity and performance. Ninety four (94) anthocyanin-derived pigments were tentatively identified in one- and six-year-old Pinotage wines using accurate mass and fragmentation information obtained using quadrupole-time-of-flight mass spectrometry (QTOP-MS). Online HLLIC X RP-LC-MS was found to offer high-resolution separation, because of the combination of two different separation modes, while the structured elution order observed improved the certainty in compound identification. Therefore, this approach shows promise for the detailed elucidation of the chemical alteration of anthocyanins during wine aging.
Changes in anthocyanin chemistry represent some of the most important transformations involved in red wine aging. However, accurate analysis of the derived pigments, as required to study the evolution of anthocyanins and tannins during aging, is hampered by their extreme structural diversity, low levels, and the fact that many of these compounds have identical mass spectral characteristics. In this context, chromatographic separation is critical. In this contribution, the application of online hydrophilic interaction chromatography (HILIC) × reversed-phase liquid chromatography (RP-LC) separation coupled to high-resolution mass spectrometry (MS) is described for the detailed characterization of anthocyanins and their derived pigments in aged red wine. A systematic approach was followed for the optimization of HILIC × RP-LC separation parameters using a capillary liquid chromatography (LC) system in the first dimension and an ultrahigh-pressure LC system in the second dimension to ensure maximum sensitivity and performance. Ninety four (94) anthocyanin-derived pigments were tentatively identified in one- and six-year-old Pinotage wines using accurate mass and fragmentation information obtained using quadrupole-time-of-flight mass spectrometry (Q-TOF-MS). Online HILIC × RP-LC-MS was found to offer high-resolution separation, because of the combination of two different separation modes, while the structured elution order observed improved the certainty in compound identification. Therefore, this approach shows promise for the detailed elucidation of the chemical alteration of anthocyanins during wine aging.
Author Tredoux, Andreas G. J
Willemse, Chandré M
Stander, Maria A
de Villiers, André
Vestner, Jochen
AuthorAffiliation Center of Analytical Chemistry and Microbiology, Department of Microbiology and Biochemistry
Department of Chemistry and Polymer Science
Stellenbosch University
Department of Biochemistry
Central Analytical Facility
Hochschule Geisenheim University
AuthorAffiliation_xml – name: Center of Analytical Chemistry and Microbiology, Department of Microbiology and Biochemistry
– name: Hochschule Geisenheim University
– name: Department of Chemistry and Polymer Science
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Author_xml – sequence: 1
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  surname: Willemse
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– sequence: 2
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  surname: Stander
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– sequence: 5
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  surname: de Villiers
  fullname: de Villiers, André
  email: ajdevill@sun.ac.za
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26554292$$D View this record in MEDLINE/PubMed
https://hal.inrae.fr/hal-02638514$$DView record in HAL
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Cites_doi 10.1016/j.aca.2005.11.028
10.1002/jms.1208
10.1021/jf0340963
10.1016/j.chroma.2014.06.086
10.1002/jms.1044
10.1016/j.aca.2007.11.034
10.1016/S0031-9422(96)00707-8
10.1039/p19960000735
10.1021/jf0111561
10.1016/S0031-9422(97)00772-3
10.1021/jf8021496
10.1002/jssc.201000811
10.5344/ajev.2003.54.3.163
10.1016/j.chroma.2009.06.071
10.1016/S0021-9673(03)00495-3
10.1021/jf011261a
10.1021/jf0345402
10.1016/j.chroma.2013.03.009
10.1016/j.chroma.2009.02.038
10.1016/j.chroma.2014.02.051
10.1016/j.foodchem.2010.01.060
10.1002/jssc.201200060
10.1016/S0021-9673(04)01291-9
10.1021/jf9609587
10.1016/j.chroma.2008.12.073
10.1021/ac3020214
10.1021/jf00054a006
10.1016/j.talanta.2013.12.066
10.1111/j.1755-0238.2012.00190.x
10.1021/jf062325q
10.1177/108201329900500407
10.1002/(SICI)1097-0010(20000501)80:6<745::AID-JSFA611>3.0.CO;2-4
10.1002/jssc.200900673
10.1155/2013/274893
10.1016/S0021-9673(96)00485-2
10.1016/j.aca.2003.11.084
10.1021/ac801772u
10.1016/j.chroma.2014.07.044
10.3390/molecules17021571
10.1016/j.chroma.2013.10.045
10.1021/jf048939h
10.5344/ajev.1976.27.3.97
10.1016/j.foodchem.2008.09.001
10.1021/jf981286i
10.1021/jf101408q
10.1021/ac401896r
10.1016/j.chroma.2012.10.041
10.1021/jf960252c
10.1016/0308-8146(87)90147-6
10.1016/j.chroma.2005.03.008
10.3390/molecules13123007
10.1016/j.chroma.2011.11.062
10.1016/j.chroma.2012.02.058
10.1016/j.chroma.2010.06.048
10.1007/s00216-014-8036-9
10.1016/j.chroma.2011.05.042
10.1007/s00216-010-4479-9
10.1021/ac202317m
10.1016/j.chroma.2013.03.008
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References ref9/cit9
ref45/cit45
ref3/cit3
ref27/cit27
Timberlake C. F. (ref50/cit50) 1976; 27
ref56/cit56
ref16/cit16
ref52/cit52
ref23/cit23
ref8/cit8
ref31/cit31
ref59/cit59
ref2/cit2
ref34/cit34
ref37/cit37
ref20/cit20
ref48/cit48
ref17/cit17
ref10/cit10
ref35/cit35
ref53/cit53
ref19/cit19
ref21/cit21
ref46/cit46
Schwarz M. (ref60/cit60) 2003; 42
ref49/cit49
ref13/cit13
Jackson R. S. (ref42/cit42) 2008
ref61/cit61
ref24/cit24
ref38/cit38
ref54/cit54
ref6/cit6
ref36/cit36
ref18/cit18
ref11/cit11
ref25/cit25
ref29/cit29
ref32/cit32
ref39/cit39
ref14/cit14
ref57/cit57
ref5/cit5
ref51/cit51
ref43/cit43
ref28/cit28
ref40/cit40
ref26/cit26
ref12/cit12
ref15/cit15
ref41/cit41
ref58/cit58
ref22/cit22
ref33/cit33
ref4/cit4
ref30/cit30
Monagas M. (ref55/cit55) 2003; 54
ref47/cit47
ref1/cit1
ref44/cit44
ref7/cit7
References_xml – ident: ref40/cit40
  doi: 10.1016/j.aca.2005.11.028
– ident: ref5/cit5
  doi: 10.1002/jms.1208
– ident: ref11/cit11
  doi: 10.1021/jf0340963
– ident: ref34/cit34
  doi: 10.1016/j.chroma.2014.06.086
– ident: ref41/cit41
  doi: 10.1002/jms.1044
– ident: ref57/cit57
  doi: 10.1016/j.aca.2007.11.034
– ident: ref8/cit8
  doi: 10.1016/S0031-9422(96)00707-8
– ident: ref10/cit10
  doi: 10.1039/p19960000735
– ident: ref53/cit53
  doi: 10.1021/jf0111561
– ident: ref9/cit9
  doi: 10.1016/S0031-9422(97)00772-3
– ident: ref56/cit56
  doi: 10.1021/jf8021496
– ident: ref18/cit18
  doi: 10.1002/jssc.201000811
– volume: 54
  start-page: 163
  year: 2003
  ident: ref55/cit55
  publication-title: Am. J. Enol. Vitic.
  doi: 10.5344/ajev.2003.54.3.163
  contributor:
    fullname: Monagas M.
– ident: ref19/cit19
  doi: 10.1016/j.chroma.2009.06.071
– ident: ref24/cit24
  doi: 10.1016/S0021-9673(03)00495-3
– volume-title: Wine Science: Principles and Applications
  year: 2008
  ident: ref42/cit42
  contributor:
    fullname: Jackson R. S.
– ident: ref54/cit54
  doi: 10.1021/jf011261a
– ident: ref44/cit44
  doi: 10.1021/jf0345402
– ident: ref27/cit27
  doi: 10.1016/j.chroma.2013.03.009
– ident: ref15/cit15
  doi: 10.1016/j.chroma.2009.02.038
– ident: ref35/cit35
  doi: 10.1016/j.chroma.2014.02.051
– ident: ref43/cit43
  doi: 10.1016/j.foodchem.2010.01.060
– ident: ref21/cit21
  doi: 10.1002/jssc.201200060
– ident: ref38/cit38
  doi: 10.1016/S0021-9673(04)01291-9
– ident: ref49/cit49
  doi: 10.1021/jf9609587
– ident: ref29/cit29
  doi: 10.1016/j.chroma.2008.12.073
– ident: ref31/cit31
  doi: 10.1021/ac3020214
– ident: ref13/cit13
  doi: 10.1021/jf00054a006
– ident: ref48/cit48
  doi: 10.1016/j.talanta.2013.12.066
– ident: ref47/cit47
  doi: 10.1111/j.1755-0238.2012.00190.x
– ident: ref12/cit12
  doi: 10.1021/jf062325q
– ident: ref52/cit52
  doi: 10.1177/108201329900500407
– ident: ref3/cit3
  doi: 10.1002/(SICI)1097-0010(20000501)80:6<745::AID-JSFA611>3.0.CO;2-4
– ident: ref20/cit20
  doi: 10.1002/jssc.200900673
– ident: ref51/cit51
  doi: 10.1155/2013/274893
– ident: ref4/cit4
  doi: 10.1016/S0021-9673(96)00485-2
– ident: ref45/cit45
  doi: 10.1016/j.aca.2003.11.084
– ident: ref30/cit30
  doi: 10.1021/ac801772u
– ident: ref22/cit22
  doi: 10.1016/j.chroma.2014.07.044
– ident: ref39/cit39
  doi: 10.3390/molecules17021571
– ident: ref17/cit17
  doi: 10.1016/j.chroma.2013.10.045
– ident: ref6/cit6
  doi: 10.1021/jf048939h
– volume: 27
  start-page: 97
  year: 1976
  ident: ref50/cit50
  publication-title: Am. J. Enol. Vitic.
  doi: 10.5344/ajev.1976.27.3.97
  contributor:
    fullname: Timberlake C. F.
– ident: ref2/cit2
  doi: 10.1016/j.foodchem.2008.09.001
– ident: ref59/cit59
  doi: 10.1021/jf981286i
– volume: 42
  start-page: 105
  year: 2003
  ident: ref60/cit60
  publication-title: Vitis
  contributor:
    fullname: Schwarz M.
– ident: ref61/cit61
  doi: 10.1021/jf101408q
– ident: ref23/cit23
  doi: 10.1021/ac401896r
– ident: ref26/cit26
  doi: 10.1016/j.chroma.2012.10.041
– ident: ref7/cit7
  doi: 10.1021/jf960252c
– ident: ref1/cit1
  doi: 10.1016/0308-8146(87)90147-6
– ident: ref28/cit28
  doi: 10.1016/j.chroma.2005.03.008
– ident: ref46/cit46
  doi: 10.3390/molecules13123007
– ident: ref37/cit37
  doi: 10.1016/j.chroma.2011.11.062
– ident: ref14/cit14
  doi: 10.1016/j.chroma.2012.02.058
– ident: ref32/cit32
  doi: 10.1016/j.chroma.2010.06.048
– ident: ref36/cit36
  doi: 10.1007/s00216-014-8036-9
– ident: ref16/cit16
  doi: 10.1016/j.chroma.2011.05.042
– ident: ref58/cit58
  doi: 10.1007/s00216-010-4479-9
– ident: ref33/cit33
  doi: 10.1021/ac202317m
– ident: ref25/cit25
  doi: 10.1016/j.chroma.2013.03.008
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Snippet Changes in anthocyanin chemistry represent some of the most important transformations involved in red wine aging. However, accurate analysis of the derived...
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SubjectTerms Anthocyanins - analysis
Chromatography, Liquid
Chromatography, Reverse-Phase
Food Analysis - methods
Hydrophobic and Hydrophilic Interactions
Life Sciences
Mass Spectrometry
Pigments, Biological - analysis
Wine - analysis
Title Comprehensive Two-Dimensional Hydrophilic Interaction Chromatography (HILIC) × Reversed-Phase Liquid Chromatography Coupled to High-Resolution Mass Spectrometry (RP-LC-UV-MS) Analysis of Anthocyanins and Derived Pigments in Red Wine
URI http://dx.doi.org/10.1021/acs.analchem.5b03615
https://www.ncbi.nlm.nih.gov/pubmed/26554292
https://search.proquest.com/docview/1749610251
https://hal.inrae.fr/hal-02638514
Volume 87
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