Degradable Gelatin-Based IPN Cryogel Hemostat for Rapidly Stopping Deep Noncompressible Hemorrhage and Simultaneously Improving Wound Healing
Biodegradable cryogel wound dressing which can stop deep noncompressible hemorrhage and simultaneously promote wound healing is a highly promising biomaterial in clinics. Here, we prepared a series of biodegradable interpenetrating polymer network (IPN) dry cryogel hemostats by cryo-polymerization o...
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| Published in | Chemistry of materials Vol. 32; no. 15; pp. 6595 - 6610 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
American Chemical Society
11.08.2020
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| Online Access | Get full text |
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| Abstract | Biodegradable cryogel wound dressing which can stop deep noncompressible hemorrhage and simultaneously promote wound healing is a highly promising biomaterial in clinics. Here, we prepared a series of biodegradable interpenetrating polymer network (IPN) dry cryogel hemostats by cryo-polymerization of gelatin and dopamine. The IPN structure of cross-linked gelatin and polydopamine endows the cryogels good injectability, robust mechanical property, and shape memory property. The cryogels showed better whole blood-clotting capacity and more blood cell and platelet adhesion and activation than gauze and gelatin hemostatic sponge. The cryogels present less blood loss and shorter hemostasis time than gauze and gelatin hemostatic sponges in the mouse liver trauma model, rat liver incision model, and rabbit liver cross incision model. Especially, the hemostatic effect of the cryogel on deep narrow noncompressible hemorrhage was determined by the rabbit liver defect deep narrow noncompressible hemorrhage model. The cryogel rapidly stopped deep massive noncompressible hemorrhage in the swine subclavian artery and vein complete transection model. Besides, the component of polydopamine endows cryogels with excellent antioxidant activity and NIR irradiation-assisted photothermal antibacterial ability. Gelatin/dopamine cryogels were more effective in promoting wound healing than Tegaderm films. The developed biodegradable cryogels with a simple preparation process and low cost and which can be easily carried and used present huge potential as novel wound dressing for rapid hemostasis and promoting wound healing. |
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| AbstractList | Biodegradable cryogel wound dressing which can stop deep noncompressible hemorrhage and simultaneously promote wound healing is a highly promising biomaterial in clinics. Here, we prepared a series of biodegradable interpenetrating polymer network (IPN) dry cryogel hemostats by cryo-polymerization of gelatin and dopamine. The IPN structure of cross-linked gelatin and polydopamine endows the cryogels good injectability, robust mechanical property, and shape memory property. The cryogels showed better whole blood-clotting capacity and more blood cell and platelet adhesion and activation than gauze and gelatin hemostatic sponge. The cryogels present less blood loss and shorter hemostasis time than gauze and gelatin hemostatic sponges in the mouse liver trauma model, rat liver incision model, and rabbit liver cross incision model. Especially, the hemostatic effect of the cryogel on deep narrow noncompressible hemorrhage was determined by the rabbit liver defect deep narrow noncompressible hemorrhage model. The cryogel rapidly stopped deep massive noncompressible hemorrhage in the swine subclavian artery and vein complete transection model. Besides, the component of polydopamine endows cryogels with excellent antioxidant activity and NIR irradiation-assisted photothermal antibacterial ability. Gelatin/dopamine cryogels were more effective in promoting wound healing than Tegaderm films. The developed biodegradable cryogels with a simple preparation process and low cost and which can be easily carried and used present huge potential as novel wound dressing for rapid hemostasis and promoting wound healing. |
| Author | Zhao, Xin Guo, Baolin Zhang, Zhiyi Han, Yong Yin, Zhanhai Liang, Yongping Chen, Baojun Huang, Ying Bai, Lang |
| AuthorAffiliation | Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology The First Affiliated Hospital of Xi’an Jiaotong University Xi’an Jiaotong University Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials Department of Orthopaedics |
| AuthorAffiliation_xml | – name: Department of Orthopaedics – name: The First Affiliated Hospital of Xi’an Jiaotong University – name: Xi’an Jiaotong University – name: Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials – name: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology |
| Author_xml | – sequence: 1 givenname: Ying surname: Huang fullname: Huang, Ying organization: Xi’an Jiaotong University – sequence: 2 givenname: Xin surname: Zhao fullname: Zhao, Xin organization: Xi’an Jiaotong University – sequence: 3 givenname: Zhiyi surname: Zhang fullname: Zhang, Zhiyi organization: Xi’an Jiaotong University – sequence: 4 givenname: Yongping orcidid: 0000-0001-6335-0428 surname: Liang fullname: Liang, Yongping organization: Xi’an Jiaotong University – sequence: 5 givenname: Zhanhai surname: Yin fullname: Yin, Zhanhai organization: The First Affiliated Hospital of Xi’an Jiaotong University – sequence: 6 givenname: Baojun surname: Chen fullname: Chen, Baojun organization: The First Affiliated Hospital of Xi’an Jiaotong University – sequence: 7 givenname: Lang surname: Bai fullname: Bai, Lang organization: The First Affiliated Hospital of Xi’an Jiaotong University – sequence: 8 givenname: Yong orcidid: 0000-0002-4741-9058 surname: Han fullname: Han, Yong organization: Xi’an Jiaotong University – sequence: 9 givenname: Baolin orcidid: 0000-0001-6756-1441 surname: Guo fullname: Guo, Baolin email: baoling@mail.xjtu.edu.cn organization: Xi’an Jiaotong University |
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| Title | Degradable Gelatin-Based IPN Cryogel Hemostat for Rapidly Stopping Deep Noncompressible Hemorrhage and Simultaneously Improving Wound Healing |
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