Inner and Outer Surface Functionalizations of Ultrasmall Fluorescent Silica Nanorings As Shown by High-Performance Liquid Chromatography
In the past two decades, ultrasmall fluorescent nanomaterials have garnered significant interest in the fields of bioimaging and nanomedicine. More recently, attention has shifted from purely spherical nanoparticles to objects with a variety of different shapes, such as high-aspect-ratio, hollow, an...
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Published in | Chemistry of materials Vol. 31; no. 15; pp. 5519 - 5528 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
American Chemical Society
13.08.2019
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Abstract | In the past two decades, ultrasmall fluorescent nanomaterials have garnered significant interest in the fields of bioimaging and nanomedicine. More recently, attention has shifted from purely spherical nanoparticles to objects with a variety of different shapes, such as high-aspect-ratio, hollow, and star-shaped nanomaterials. We have recently reported the synthesis and characterization of ultrasmall silica nanoparticles with complex shapes, including silica nanocages, silica nanorings, and single-pore silica nanoparticles. Here, we focus on fluorescent silica nanorings that are of particular interest for theranostic applications in nanomedicine. We present in-depth studies of the synthesis and orthogonal surface functionalization, successfully distinguishing the inside and outside of the silica nanorings, utilizing a combination of spectroscopic and analytical techniques including fluorescence correlation spectroscopy and reversed-phase high-performance liquid chromatography. Results suggest that despite the small silica ring diameter of around 10 nm and below, it is possible to effectively “hide” hydrophobic moieties on the inside of the rings but that their number must be carefully engineered. We expect the chemistry and methods developed here to be of interest to a range of differently shaped porous nanoparticles within the ultrasmall-size regime. |
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AbstractList | In the past two decades, ultrasmall fluorescent nanomaterials have garnered significant interest in the fields of bioimaging and nanomedicine. More recently, attention has shifted from purely spherical nanoparticles to objects with a variety of different shapes, such as high-aspect-ratio, hollow, and star-shaped nanomaterials. We have recently reported the synthesis and characterization of ultrasmall silica nanoparticles with complex shapes, including silica nanocages, silica nanorings, and single-pore silica nanoparticles. Here, we focus on fluorescent silica nanorings that are of particular interest for theranostic applications in nanomedicine. We present in-depth studies of the synthesis and orthogonal surface functionalization, successfully distinguishing the inside and outside of the silica nanorings, utilizing a combination of spectroscopic and analytical techniques including fluorescence correlation spectroscopy and reversed-phase high-performance liquid chromatography. Results suggest that despite the small silica ring diameter of around 10 nm and below, it is possible to effectively “hide” hydrophobic moieties on the inside of the rings but that their number must be carefully engineered. We expect the chemistry and methods developed here to be of interest to a range of differently shaped porous nanoparticles within the ultrasmall-size regime. |
Author | Kohle, Ferdinand F. E Contreras, Cintia B Wiesner, Ulrich B Woodruff, Fem Ma, Kai Turker, Melik Z Gardinier, Thomas C Hinckley, Joshua A |
AuthorAffiliation | Robert Frederick Smith School of Chemical and Biomolecular Engineering Nanosystems Institute Elucida Oncology Inc Department of Materials Science and Engineering Department of Chemistry and Chemical Biology |
AuthorAffiliation_xml | – name: Robert Frederick Smith School of Chemical and Biomolecular Engineering – name: – name: Department of Chemistry and Chemical Biology – name: Elucida Oncology Inc – name: Nanosystems Institute – name: Department of Materials Science and Engineering |
Author_xml | – sequence: 1 givenname: Melik Z orcidid: 0000-0001-7801-4275 surname: Turker fullname: Turker, Melik Z – sequence: 2 givenname: Thomas C orcidid: 0000-0002-9442-3770 surname: Gardinier fullname: Gardinier, Thomas C – sequence: 3 givenname: Joshua A orcidid: 0000-0002-0575-5045 surname: Hinckley fullname: Hinckley, Joshua A – sequence: 4 givenname: Cintia B surname: Contreras fullname: Contreras, Cintia B organization: Nanosystems Institute – sequence: 5 givenname: Fem surname: Woodruff fullname: Woodruff, Fem – sequence: 6 givenname: Kai orcidid: 0000-0003-4415-6894 surname: Ma fullname: Ma, Kai organization: Elucida Oncology Inc – sequence: 7 givenname: Ferdinand F. E orcidid: 0000-0002-7351-5940 surname: Kohle fullname: Kohle, Ferdinand F. E – sequence: 8 givenname: Ulrich B orcidid: 0000-0001-6934-3755 surname: Wiesner fullname: Wiesner, Ulrich B email: ubw1@cornell.edu |
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Title | Inner and Outer Surface Functionalizations of Ultrasmall Fluorescent Silica Nanorings As Shown by High-Performance Liquid Chromatography |
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