Noble Metal versus Abundant Metal Catalysts in Fine Organic Synthesis: Cost Comparison of C–H Activation Methods
There is a common assumption that replacement of the classical catalyst based on rare and expensive noble metals by the catalysts based on earth-abundant metals will dramatically reduce the costs of organic synthesis. Herein we demonstrate that it may not be true, mainly because sophisticated organi...
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| Published in | Organometallics Vol. 42; no. 13; pp. 1433 - 1438 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
American Chemical Society
10.07.2023
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| Online Access | Get full text |
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| Abstract | There is a common assumption that replacement of the classical catalyst based on rare and expensive noble metals by the catalysts based on earth-abundant metals will dramatically reduce the costs of organic synthesis. Herein we demonstrate that it may not be true, mainly because sophisticated organic substrates and modern reagents are often as expensive as catalytic amounts of noble metals. The particular cost analysis of the syntheses of 3,4-diphenyl-isoquinolone by various C–H activation methods revealed that the main costs fall on the stoichiometric reagents rather than the catalysts. As a result, the metal-free synthesis appears to be even more expensive than the procedures involving ruthenium and rhodium catalysts. Overall, metal prices should not be considered the sole reason for conducting academic research without any preliminary analysis. |
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| AbstractList | There is a common assumption that replacement of the classical catalyst based on rare and expensive noble metals by the catalysts based on earth-abundant metals will dramatically reduce the costs of organic synthesis. Herein we demonstrate that it may not be true, mainly because sophisticated organic substrates and modern reagents are often as expensive as catalytic amounts of noble metals. The particular cost analysis of the syntheses of 3,4-diphenyl-isoquinolone by various C–H activation methods revealed that the main costs fall on the stoichiometric reagents rather than the catalysts. As a result, the metal-free synthesis appears to be even more expensive than the procedures involving ruthenium and rhodium catalysts. Overall, metal prices should not be considered the sole reason for conducting academic research without any preliminary analysis. |
| Author | Komarova, Alina A. Perekalin, Dmitry S. |
| AuthorAffiliation | A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences National Research University Higher School of Economics |
| AuthorAffiliation_xml | – name: Russian Academy of Sciences – name: A.N. Nesmeyanov Institute of Organoelement Compounds – name: National Research University Higher School of Economics |
| Author_xml | – sequence: 1 givenname: Alina A. surname: Komarova fullname: Komarova, Alina A. organization: Russian Academy of Sciences – sequence: 2 givenname: Dmitry S. orcidid: 0000-0002-0864-8907 surname: Perekalin fullname: Perekalin, Dmitry S. email: dsp@ineos.ac.ru organization: National Research University Higher School of Economics |
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| Title | Noble Metal versus Abundant Metal Catalysts in Fine Organic Synthesis: Cost Comparison of C–H Activation Methods |
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