3‑Substituted 1,5-Diaryl‑1H‑1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX‑1 in Monkey. Part 1: Synthesis and Pharmacology

• Published in: ACS chemical neuroscience Vol. 9; no. 11; pp. 2610 - 2619
• Main Authors: Singh, Prachi, Shrestha, Stal, Cortes-Salva, Michelle Y, Jenko, Kimberly J, Zoghbi, Sami S, Morse, Cheryl L, Innis, Robert B, Pike, Victor W
• Format: Journal Article
• Language: English
• Published: American Chemical Society 21.11.2018
• Subjects: radioligand; carbon-11; fluorine-18; brain; COX-1; PET

Cyclooxygenase-1 (COX-1) is a key enzyme in the biosynthesis of proinflammatory thromboxanes and prostaglandins and is found in glial and neuronal cells within brain. COX-1 expression is implicated in numerous neuroinflammatory states. We aim to find a direct-acting positron emission tomography (PET...