Ultrasensitive SERS Detection of Five β‑Blockers Achieved Using Chemometrics with a Two-Dimensional Substrate Formed by Large-Sized Ag@SiO2 Nanoparticles

• Published in: Analytical chemistry (Washington) Vol. 96; no. 41; pp. 16379 - 16386
• Main Authors: Cheng, Tao, Xie, Ziyue, Wang, Tianrun, Jiang, Yuning, Guo, Xiaoyu, Liu, Xinling, Wen, Ying, Yang, Haifeng, Wu, Yiping
• Format: Journal Article
• Language: English
• Published: Washington American Chemical Society 15.10.2024
• Subjects: Atenolol; Beta blockers; beta-adrenergic antagonists; chemometrics; Cluster analysis; Detection limits; Drug screening; Drugs; electromagnetic field; Electromagnetic fields; humans; Nanoparticles; principal component analysis; Principal components analysis; Propranolol; Raman spectra; Raman spectroscopy; Self-assembly; silicon; Silicon dioxide; Silicon wafers; Silver; spectral analysis; Target detection; urine

We report on a surface-enhanced Raman scattering (SERS) platform for the detection of five beta-blockers (β-blockers): atenolol, esmolol, labetalol, sotalol, and propranolol. Key to this platform was a two-dimensional substrate formed by self-assembling large Ag@SiO2 nanoparticles (Ag@SiO2 NPs) on a...