Cocrystal Systems of Pharmaceutical Interest: 2011

The literature published during 2011 whose subject matter encompasses the cocrystallization of organic compounds having particular interest to pharmaceutical scientists has been summarized in an annual review. The papers cited in this review were drawn from the major physical, crystallographic, and...

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Published inCrystal growth & design Vol. 12; no. 11; pp. 5823 - 5832
Main Author Brittain, Harry G
Format Journal Article
LanguageEnglish
Published Washington,DC American Chemical Society 07.11.2012
Subjects
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science; rheology
Equations of state, phase equilibria, and phase transitions
Exact sciences and technology
Materials science
Methods of crystal growth; physics of crystal growth
Physics
Solid-solid transitions
Specific phase transitions
Crystal growth
Drugs
Reviews
Cocrystal
Crystallization
Cocrystallization
Organic compounds
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Abstract The literature published during 2011 whose subject matter encompasses the cocrystallization of organic compounds having particular interest to pharmaceutical scientists has been summarized in an annual review. The papers cited in this review were drawn from the major physical, crystallographic, and pharmaceutical journals. After a brief introduction, the review is divided into sections that cover articles of general interest, the preparation of cocrystal systems and methodologies for their characterization, and more detailed discussion of cocrystal systems containing pharmaceutically relevant compounds. The review ends with a discussion of the draft Guidance for Industry document regarding the regulatory classification of pharmaceutical cocrystals that was issued at the end of 2011 by the Center for Drug Evaluation and Research (CDER) of the United States Food and Drug Administration.
AbstractList The literature published during 2011 whose subject matter encompasses the cocrystallization of organic compounds having particular interest to pharmaceutical scientists has been summarized in an annual review. The papers cited in this review were drawn from the major physical, crystallographic, and pharmaceutical journals. After a brief introduction, the review is divided into sections that cover articles of general interest, the preparation of cocrystal systems and methodologies for their characterization, and more detailed discussion of cocrystal systems containing pharmaceutically relevant compounds. The review ends with a discussion of the draft Guidance for Industry document regarding the regulatory classification of pharmaceutical cocrystals that was issued at the end of 2011 by the Center for Drug Evaluation and Research (CDER) of the United States Food and Drug Administration.
Author Brittain, Harry G
AuthorAffiliation Center for Pharmaceutical Physics
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Issue 11
Keywords Crystal growth
Drugs
Reviews
Cocrystal
Crystallization
Cocrystallization
Organic compounds
Language English
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Snippet The literature published during 2011 whose subject matter encompasses the cocrystallization of organic compounds having particular interest to pharmaceutical...
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SubjectTerms Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science; rheology
Equations of state, phase equilibria, and phase transitions
Exact sciences and technology
Materials science
Methods of crystal growth; physics of crystal growth
Physics
Solid-solid transitions
Specific phase transitions
Title Cocrystal Systems of Pharmaceutical Interest: 2011
URI http://dx.doi.org/10.1021/cg301114f
Volume 12
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