Crystallization Features of the Chiral Drug Timolol Precursor: The Rare Case of Conglomerate with Partial Solid Solutions

• Published in: Crystal growth & design Vol. 14; no. 4; pp. 1676 - 1683
• Main Authors: Bredikhin, Alexander A, Zakharychev, Dmitry V, Gubaidullin, Aidar T, Fayzullin, Robert R, Pashagin, Alexander V, Bredikhina, Zemfira A
• Format: Journal Article
• Language: English; Russian
• Published: Washington,DC American Chemical Society 02.04.2014

A synthetic precursor of the chiral drug timolol, 4-[4-(oxiran-2-ylmethoxy)-1,2,5-thiadiazol-3-yl]-morpholine (2) represents a rare case of conglomerate with partial solid solution. This fact was established by inspection of an original solubility test, by the originally developed IR spectra analysi...