Combined Exposure to 3‑Chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone and Microsytin-LR Increases Genotoxicity in Chinese Hamster Ovary Cells through Oxidative Stress

• Published in: Environmental science & technology Vol. 47; no. 3; pp. 1678 - 1687
• Main Authors: Wang, Shu, Tian, Dajun, Zheng, Weiwei, Jiang, Songhui, Wang, Xia, Andersen, Melvin E, Zheng, Yuxin, He, Gensheng, Qu, Weidong
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 05.02.2013
• Subjects: Animals; Antioxidants - metabolism; Biological and medical sciences; Breath tests; Cell Death - drug effects; Chemical and industrial products toxicology. Toxic occupational diseases; Chemical contaminants; CHO Cells; Comet Assay; Cricetinae; Cricetulus; Cytokines; Drinking water; Environmental Exposure; Epidemiology. Vaccinations; Food toxicology; Furans - toxicity; Gastric cancer; General aspects; Glutathione - metabolism; Infectious diseases; Luciferases - metabolism; Medical sciences; Microcystins - toxicity; Micronucleus Tests; Mutagenicity Tests; Mutagens - toxicity; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Reactive Oxygen Species - metabolism; Rodents; Toxicity; Toxicology; Various organic compounds; Drinking water treatment; Oxidative stress; Toxicity; Chlorine Organic compounds; DNA; Furan derivatives; Genotoxicity; Disinfection; In vitro; By product; Toxic association

The disinfection byproducts 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone (MX) and microcystins-LR (MC-LR), which are common contaminants in drinking water, often occur together in water sources in areas with high gastrointestinal tract cancer risks. While often studied alone, combination effec...