Functional genomics and proteomics in the clinical neurosciences
The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations.To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both...
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| Published in | Progress in brain research Vol. v.Volume 158 |
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| Main Authors | , |
| Format | eBook Book |
| Language | English |
| Published |
Amsterdam ; Boston
Elsevier
2006
Elsevier Science & Technology Elsevier Science |
| Edition | 1 |
| Series | Progress in brain research |
| Subjects | |
| Online Access | Get full text |
| ISBN | 9780444518538 0444518533 |
| ISSN | 0079-6123 |
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| Abstract | The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations.To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would. |
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| AbstractList | The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses.
* Introduction of basic methodologies in genomics and proteomics and their integration in psychiatry* Development of the text in sections related to methods, application and future directions of these rapidly advancing technologies* Use of actual data to illustrate many principles of functional genomics and proteomics. * Introduction to bioinformatics and database management techniques The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations.To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would. |
| Author | Hemby, S. E Bahn, S |
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| Snippet | The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations.To know... The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know... |
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| SubjectTerms | Biological and medical sciences Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Genomics Neurobehavioral disorders Neurobehavioral disorders - Molecular aspects Neurobehavioral disorders -- Genetic aspects Neurogenetics Proteomics Vertebrates: nervous system and sense organs |
| TableOfContents | Cover -- Functional Genomics and Proteomics in the Clinical Neurosciences -- Copyright Page -- List of Contributors -- Foreword -- Contents -- Section I: Methodologies -- Chapter 1: Tissue preparation and banking -- Introduction -- Identifying subjects -- Collection and harvesting tissue -- Documenting -- RNA integrity -- Protein integrity -- Conclusions -- References -- Chapter 2: Functional genomic methodologies -- Introduction -- Input sources of RNA -- Gene expression profiling: toward an informed choice -- Level of sensitivity to detect the molecules of interest -- Magnitude of expression-level changes in the brain -- Minimum starting material for functional genomic analysis -- Verification of expression-profiling analysis -- Conventional methods of analyzing gene expression: Northern hybridization -- qPCR -- Serial analysis of gene expression (SAGE) -- Massive parallel signature sequencing (MPSS) -- Total analysis of gene expression (TOGA) -- Sequencing by hybridization (SBH) -- Microarray platforms -- Analyzing massive datasets -- Regional and single cell assessment -- RNA amplification strategies: aRNA amplification -- Additional considerations -- Conclusions -- Acknowledgements -- References -- Chapter 3: Methods for proteomics in neuroscience -- Introduction -- Subcellular fractionation -- Expression proteomics -- Functional proteomics -- Mass spectrometry -- Protein arrays -- Conclusion -- References -- Chapter 4: Functional genomics and proteomics in the clinical neurosciences: data mining and bioinformatics -- Introduction -- Experimental methods -- Data analysis -- Statistical analysis and pattern classification -- Microarray case study -- Interpretation and validation -- Acknowledgments -- References -- Chapter 5: Reproducibility of microarray studies: concordance of current analysis methods -- Introduction Regional gene expression profiling in the hippocampus in AD -- Regional gene expression profiling in frontal and temporal neocortex in AD -- Regional gene expression profiling in other AD-related brain regions -- Single cell analysis of cholinergic basal forebrain (CBF) neurons in AD -- Single cell profiling of galanin hyperinnervated CBF neurons in AD -- Summary of gene expression profiling in AD -- Parkinson's disease -- Regional gene profiling of the substantia nigra in PD -- Gene expression profiling of Lewy body-containing SNpc neurons in PD -- Summary of gene expression profiling in PD -- Schizophrenia -- Regional gene expression profiling in frontal cortex in schizophrenia -- Single cell gene profiling in the entorhinal cortex in schizophrenia -- Multiple sclerosis -- Gene profiling in multiple sclerosis -- Creutzfeld-Jakob disease -- Gene profiling in the aged brain -- Single cell profiling of aged CA1 and CA3 hippocampal neurons -- Gene regulation during the course of normal aging within the frontal cortex -- Conclusions -- Abbreviations -- Acknowledgments -- References -- Chapter 11: Epileptogenesis-related genes revisited -- Introduction -- Methods -- Results and discussion -- Concluding remarks -- Abbreviations -- Acknowledgments -- References -- Chapter 12: Functional genomics of sex hormone-dependent neuroendocrine systems: specific and generalized actions in the CNS -- Neural and genomic mechanisms for female mating behaviors -- From lordosis to sexual arousal to generalized CNS arousal -- From generalized CNS arousal to specific forms of arousal -- Molecular biology of histamine receptors in CNS -- α1B-Noradrenergic receptor signaling -- μ and δ opioid receptor signaling -- Summary and outlook -- Abbreviations -- References -- Section III: Future Directions -- Chapter 13: Implications for the practice of psychiatry -- Introduction Proteomics -- mRNA expression arrays (expressomics) -- Whole genome SNP association studies -- Use of convergent evidence -- Future directions -- References -- Chapter 14: Human brain evolution -- Anatomical evolution -- Protein sequence evolution -- Gene expression evolution -- Theory of gene expression evolution -- Adaptive human brain evolution -- Conclusion -- Acknowledgments -- References -- Subject Index The data analysis pipeline -- Assessment of data quality -- Performance comparison -- Validation -- Implications for data mining -- Summary and conclusions -- References -- Section II: Applications of Genomics and Proteomic Technologies to Clinical Neuroscience -- Chapter 6: The genomics of mood disorders -- Introduction -- Genetics of mood disorders: the progress -- Neurobiological and neuroanatomical substrates of severe mood disorders -- The pathophysiology of severe mood disorders: insights from recent gene profiling studies -- Clues from animal models -- Concluding remarks -- Acknowledgments -- References -- Chapter 7: Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortex -- Dysfunction of the DLPFC in schizophrenia -- Types of transcriptome alterations in the DLPFC in schizophrenia -- Causes of transcriptome alterations in the DLPFC in schizophrenia -- Consequences of transcriptome alterations in the DLPFC in schizophrenia -- Conclusions -- Acknowledgments -- References -- Chapter 8: Strategies for improving sensitivity of gene expression profiling: regulation of apoptosis in the limbic lobe of schizophrenics and bipolars -- Introduction -- Conclusions -- References -- Chapter 9: Assessment of genome and proteome profiles in cocaine abuse -- Introduction -- Neuroanatomy of cocaine addiction -- Functional genomics -- Proteomics -- Conclusion -- Acknowledgments -- References -- Chapter 10: Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease -- Introduction -- Alzheimer's disease -- Determination of RNA within senile plaques and neurofibrillary tangles in AD -- Single cell gene array analysis of hippocampal senile plaques in AD -- Single cell gene analysis of hippocampal NFTs in AD |
| Title | Functional genomics and proteomics in the clinical neurosciences |
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