Promoting FADH2 Regeneration of Hydroxylation for High-Level Production of Hydroxytyrosol from Glycerol in Escherichia coli

• Published in: Journal of agricultural and food chemistry Vol. 71; no. 44; pp. 16681 - 16690
• Main Authors: Wang, Huijing, Wang, Lian, Chen, Jianbin, Hu, Minglong, Fang, Fang, Zhou, Jingwen
• Format: Journal Article
• Language: English
• Published: American Chemical Society 08.11.2023
• Subjects: biochemical pathways; bioreactors; biosynthesis; Biotechnology and Biological Transformations; carbon; drugs; Escherichia coli; fermentation; food chemistry; glycerol; hydroxylation; Saccharomyces cerevisiae; tyrosine; HpaBC; hydroxytyrosol; LAAD; Escherichia coli; cofactor engineering

Hydroxytyrosol is a natural polyphenolic compound widely used in the food and drug industries. The current commercial production of hydroxytyrosol relies mainly on plant extracts, which involve long extraction cycles and various raw materials. Microbial fermentation has potential value as an environ...