Effect of an Implantable Gentamicin-Collagen Sponge on Sternal Wound Infections Following Cardiac Surgery: A Randomized Trial

• Published in: JAMA : the journal of the American Medical Association Vol. 304; no. 7; pp. 755 - 762
• Main Authors: Bennett-Guerrero, Elliott, Ferguson, T. Bruce, Lin, Min, Garg, Jyotsna, Mark, Daniel B, Scavo, Vincent A, Kouchoukos, Nicholas, Richardson, John B, Pridgen, Renee L, Corey, G. R, SWIPE-1 Trial Group, for the
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 18.08.2010
• Subjects: Aged; Anti-Bacterial Agents - administration & dosage; Antibiotics; Cardiac Surgical Procedures - instrumentation; Cardiovascular disease; Clinical trials; Female; Gentamicins - administration & dosage; Heart surgery; Humans; Male; Middle Aged; Prostheses and Implants; Risk factors; Single-Blind Method; Sternum - surgery; Surgical Sponges; Surgical Wound Infection - prevention & control; Treatment Outcome; Sweden

CONTEXT Despite the routine use of prophylactic systemic antibiotics, sternal wound infection still occurs in 5% or more of cardiac surgical patients and is associated with significant excess morbidity, mortality, and cost. The gentamicin-collagen sponge, a surgically implantable topical antibiotic,...