An Asymmetric Polymer Nanopore for Single Molecule Detection

• Published in: Nano letters Vol. 4; no. 3; pp. 497 - 501
• Main Authors: Mara, Abraham, Siwy, Zuzanna, Trautmann, Christina, Wan, Jackson, Kamme, Fredrik
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.03.2004
• Subjects: Analytical, structural and metabolic biochemistry; Biological and medical sciences; Cross-disciplinary physics: materials science; rheology; DNA, RNA; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; General aspects, investigation methods; Materials science; Nucleic acids; Physics; Surface cleaning, etching, patterning; Surface treatments; Translocation; Scanning electron microscopy; Measurement sensor; Heavy ion; Experimental study; Porous material; Engraving; DNA; Porosity; Nanopore; Electric field effect; Nanostructured materials; Organic compounds

We describe a sensor capable of detecting single DNA molecules. The sensor is based on a single nanopore prepared in a polymer film by a latent ion track-etching technique. For this purpose, a polymer foil was penetrated by a single heavy ion of total kinetic energy of 2.2 GeV, followed by preferent...