Development of Aptamer-Based Point-of-Care Diagnostic Devices for Malaria Using Three-Dimensional Printing Rapid Prototyping

• Published in: ACS sensors Vol. 1; no. 4; pp. 420 - 426
• Main Authors: Dirkzwager, Roderick M, Liang, Shaolin, Tanner, Julian A
• Format: Journal Article
• Language: English
• Published: American Chemical Society 22.04.2016
• Subjects: biosensor; malaria; aptamer; point-of-care; 3D printing

We present the adaption of an aptamer-tethered enzyme capture (APTEC) assay into point-of-care device prototypes with potential for malaria diagnosis. The assay functions by capturing the malaria biomarker Plasmodium falciparum lactate dehydrogenase (PfLDH) from samples and using its intrinsic enzym...