Discovery of Selective Inhibitors of NaV1.7 Templated on Saxitoxin as Therapeutics for Pain

The voltage-gated sodium channel isoform NaV1.7 has drawn widespread interest as a target for non-opioid, investigational new drugs to treat pain. Selectivity over homologous, off-target sodium channel isoforms, which are expressed in peripheral motor neurons, the central nervous system, skeletal mu...

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Bibliographic Details
Published inACS medicinal chemistry letters Vol. 13; no. 11; pp. 1763 - 1768
Main Authors Pajouhesh, Hassan, Delwig, Anton, Beckley, Jacob T., Klas, Sheri, Monteleone, Dennis, Zhou, Xiang, Luu, George, Du Bois, J., Hunter, John C., Mulcahy, John V.
Format Journal Article
LanguageEnglish
Published American Chemical Society 10.11.2022
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