Results of the National Institute of Allergy and Infectious Diseases Collaborative Clinical Trial to test the predictive value of skin testing with major and minor penicillin derivatives in hospitalized adults

• Published in: Archives of internal medicine (1960) Vol. 152; no. 5; p. 1025
• Main Authors: Sogn, D D, Evans, 3rd, R, Shepherd, G M, Casale, T B, Condemi, J, Greenberger, P A, Kohler, P F, Saxon, A, Summers, R J, VanArsdel, Jr, P P
• Format: Journal Article
• Language: English
• Published: United States 01.05.1992
• Subjects: Adult; Benzeneacetamides; Drug Hypersensitivity - diagnosis; Drug Hypersensitivity - epidemiology; Female; Humans; Indicators and Reagents; Inpatients; Male; Penicillin G - analogs & derivatives; Penicillins - adverse effects; Predictive Value of Tests; Skin Tests

A history (or lack thereof) of penicillin allergy is known to be unreliable in predicting reactions on subsequent administration of the drug. This study tests the usefulness of four penicillin allergen skin tests in the prediction of IgE-mediated reactions subsequent to administration of penicillin....