Palladium-Catalyzed Dual Ligand-Enabled Alkylation of Silyl Enol Ether and Enamide under Irradiation: Scope, Mechanism, and Theoretical Elucidation of Hybrid Alkyl Pd(I)-Radical Species

• Published in: ACS catalysis Vol. 10; no. 2; pp. 1334 - 1343
• Main Authors: Zhao, Bin, Shang, Rui, Wang, Guang-Zu, Wang, Shaohong, Chen, Hui, Fu, Yao
• Format: Journal Article
• Language: English
• Published: American Chemical Society 17.01.2020
• Subjects: enamide; palladium; alkylation; silyl enol ether; hybrid alkyl Pd(I)-radical species

We report herein that a palladium catalyst in combination with a dual phosphine ligand system catalyzes alkylation of silyl enol ether and enamide with a broad scope of tertiary, secondary, and primary alkyl bromides under mild irradiation conditions by blue light-emitting diodes. The reactions effe...