Catalytic Asymmetric C(sp3)–H Carbene Insertion Approach to Access Enantioenriched 3‑Fluoroalkyl 2,3-Dihydrobenzofurans

• Published in: ACS catalysis Vol. 11; no. 22; pp. 14293 - 14301
• Main Authors: Zhang, Xinyu, Sivaguru, Paramasivam, Zanoni, Giuseppe, Han, Xinyue, Tong, Minghui, Bi, Xihe
• Format: Journal Article
• Language: English
• Published: American Chemical Society 19.11.2021
• Subjects: rhodium carbene; fluoroalkyl diazo; chiral dihydrobenzofurans; fluoroalkyl N-triftosylhydrazones; asymmetric C−H insertion

Fluoroalkyl diazo compounds are versatile reagents for introducing fluoroalkyl groups into organic compounds. Despite their uses as carbene precursors in many reactions, asymmetric fluoroalkyl carbene insertion into C­(sp3)–H bonds remains quite rare. Herein we report the rhodium-catalyzed enantiose...