Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib

• Published in: Organic process research & development Vol. 27; no. 4; pp. 659 - 668
• Main Authors: Chen, Yonggang, Iuzzolino, Luca, Burgess, Samantha A., Chung, Cheol K., Corry, James, Crawford, Morgan, Desmond, Richard, Guetschow, Erik, Hartmanshenn, Clara, Kuhl, Nadine, Liu, Zhu, Luo, Hanlin, McQuilken, Alison C., Newman, Justin A., Ren, Hong, Thaisrivongs, David A., Wang, Zhixun, Sirota, Eric
• Format: Journal Article
• Language: English
• Published: American Chemical Society 21.04.2023
• Subjects: impurity crystallization kinetics; crystallization; SNAr; API; BTK inhibitor; synergistic solubility; polish filtration

We report the process development for the active pharmaceutical ingredient (API) step of the commercial manufacturing route to nemtabrutinib (MK-1026), a reversible Bruton’s Tyrosine Kinase (BTK) inhibitor currently under investigation for the treatment of several hematological malignancies. Signifi...