On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Implementation and In Situ Control of Downstream Production

• Published in: Organic process research & development Vol. 25; no. 7; pp. 1534 - 1546
• Main Authors: Capellades, Gerard, Neurohr, Clemence, Briggs, Naomi, Rapp, Kersten, Hammersmith, Gregory, Brancazio, David, Derksen, Bridget, Myerson, Allan S
• Format: Journal Article
• Language: English
• Published: American Chemical Society 16.07.2021
• Subjects: on-demand manufacturing; precipitation; continuous crystallization; drying; process control; continuous pharmaceutical manufacturing

Traditional pharmaceutical manufacturing operates around a supply chain that is subject to complex logistics and is vulnerable to spikes in demand and interruptions. In this context, continuous pharmaceutical manufacturing in portable, refrigerator-sized factories is a promising solution with applic...