Continuous Process Improvement in the Manufacture of Carfilzomib, Part 1: Process Understanding and Improvements in the Commercial Route to Prepare the Epoxyketone Warhead - Dornan, Peter K; Anthoine, Travis; Beaver, Matthew G; Cheng, Guilong Charles; Cohen, Dawn E; Cui, Sheng; Lake, William E; Langille, Neil F; Lucas, Susan P; Patel, Jenil; Roberts, Scott W; Scardino, Chris; et al. (Organic process research & development, 2020)
Keywords: α-chiral enone; epoxidation; racemization; bleach; carfilzomib