Borane-Catalyzed Reduction of Pyridines via a Hydroboration/Hydrogenation Cascade

• Published in: ACS catalysis Vol. 11; no. 17; pp. 10824 - 10829
• Main Authors: Yang, Zhao-Ying, Luo, Heng, Zhang, Ming, Wang, Xiao-Chen
• Format: Journal Article
• Language: English
• Published: American Chemical Society 03.09.2021
• Subjects: pyridine; piperidine; hydroboration; homogeneous catalysis; hydrogenation; borane

We have developed a method for a B­(C6F5)3-catalyzed hydroboration/hydrogenation cascade reduction of pyridines. The method was particularly effective for 2,3-disubstituted pyridines, which generated piperidines in high yields with high cis selectivity. Mechanistic studies indicated that the pyridin...