Synthesis, Optimization, and Large-Scale Preparation of the Low-Dose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3 + 2] Nitrone Cycloaddition - Garcia-Losada, Pablo; DeBaillie, Amy C; Eugenio de Diego, Jose; Green, Steven J; Hansen, Marvin M; Jaramillo, Carlos; Johnson, Matt; Kaoudi, Talbi; Li, Jiuyuan; Lindsay-Scott, Peter J; Mateos, Carlos; Mergott, Dustin J; et al. (Organic process research & development, 2020)
Keywords: Chemistry; Chemistry, Applied; Chemistry, Organic; Physical Sciences; Science & Technology; thermal nitrone cyclization; thiazine formation; BACE inhibitor; classical resolution; ISOXAZOLIDINES