Impact of Process Parameters on the Grinding Limit in High-Shear Wet Milling

• Published in: Organic process research & development Vol. 22; no. 9; pp. 1328 - 1333
• Main Author: Luciani, Carla V
• Format: Journal Article
• Language: English
• Published: American Chemical Society 21.09.2018
• Subjects: grinding limit; particle size; high-shear rotor−stator wet mill; pharmaceuticals; milling

Knowledge of the impact of process parameters on the minimum achievable (critical) particle size below which breakage is no longer observed for high-shear rotor–stator wet milling (HSWM) operations is vital to the design and optimization of milling processes of active pharmaceutical ingredients. The...