Impact of Process Parameters on the Grinding Limit in High-Shear Wet Milling

Knowledge of the impact of process parameters on the minimum achievable (critical) particle size below which breakage is no longer observed for high-shear rotor–stator wet milling (HSWM) operations is vital to the design and optimization of milling processes of active pharmaceutical ingredients. The...

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Published inOrganic process research & development Vol. 22; no. 9; pp. 1328 - 1333
Main Author Luciani, Carla V
Format Journal Article
LanguageEnglish
Published American Chemical Society 21.09.2018
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Abstract Knowledge of the impact of process parameters on the minimum achievable (critical) particle size below which breakage is no longer observed for high-shear rotor–stator wet milling (HSWM) operations is vital to the design and optimization of milling processes of active pharmaceutical ingredients. The grinding limit is a result of a balance between material properties and the energy imparted to particles during the milling processes. In turn, the energy imparted to particles depends on the rotation rate, generator geometry, mill configuration, flow rate, etc. In this communication, a master curve was constructed by normalizing critical particle size curves obtained at different cumulative breakage energies using a shift factor that can be determined with minimal experimentation.
AbstractList Knowledge of the impact of process parameters on the minimum achievable (critical) particle size below which breakage is no longer observed for high-shear rotor–stator wet milling (HSWM) operations is vital to the design and optimization of milling processes of active pharmaceutical ingredients. The grinding limit is a result of a balance between material properties and the energy imparted to particles during the milling processes. In turn, the energy imparted to particles depends on the rotation rate, generator geometry, mill configuration, flow rate, etc. In this communication, a master curve was constructed by normalizing critical particle size curves obtained at different cumulative breakage energies using a shift factor that can be determined with minimal experimentation.
Author Luciani, Carla V
AuthorAffiliation Small Molecule Design and Development, Lilly Research Laboratories
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CitedBy_id crossref_primary_10_1021_acs_cgd_1c01510
crossref_primary_10_1021_acs_cgd_0c00847
crossref_primary_10_1016_j_ijpharm_2018_10_073
crossref_primary_10_1016_j_ejps_2024_106780
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Keywords grinding limit
particle size
high-shear rotor−stator wet mill
pharmaceuticals
milling
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Title Impact of Process Parameters on the Grinding Limit in High-Shear Wet Milling
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