Rh(II)-Catalyzed Enynal Cycloisomerization for the Generation of Vinyl Carbene: Divergent Access to Polycyclic Heterocycles

• Published in: ACS catalysis Vol. 13; no. 1; pp. 132 - 140
• Main Authors: Wu, Rui, Chen, Yang, Zhu, Shifa
• Format: Journal Article
• Language: English
• Published: American Chemical Society 06.01.2023
• Subjects: Rh(II) catalysis; vinyl carbene; formal allylation; polycyclic heterocycles; [2 + 3] cycloaddition; cycloisomerization

Described herein is an unprecedented example of generating the endocyclic donor–donor vinyl carbene achieved by the dirhodium­(II)-catalyzed enynal cycloisomerization. The endocyclic vinyl carbene intermediate could be trapped by a diversity of alkenes, including 1,1-disubstituted alkenes, dienes, a...