A Holistic Strategy for Cyanide Control and Safety for Pharmaceutical Manufacturing

• Published in: Organic process research & development Vol. 25; no. 8; pp. 1937 - 1942
• Main Authors: Zompa, Michael A, Di Maso, Michael J, Guzman, Francisco, Zhao, Ralph, Jellett, Lisa, Arvary, Rebecca, Song, Siqing, Chang, Darryl, Ren, Hong, Lohani, Sachin
• Format: Journal Article
• Language: English
• Published: American Chemical Society 20.08.2021
• Subjects: electrochemical detection; cyanide; control strategy; safety; chloroacetonitrile; ion chromatography

The manufacturing route toward gefapixant citrate generates a trace amount of cyanide as a byproduct of a reaction employing the reagent chloroacetonitrile. In the development of a cyanide control strategy, conventional process and analytical approaches fell short because of challenges and incompati...