A Holistic Strategy for Cyanide Control and Safety for Pharmaceutical Manufacturing

The manufacturing route toward gefapixant citrate generates a trace amount of cyanide as a byproduct of a reaction employing the reagent chloroacetonitrile. In the development of a cyanide control strategy, conventional process and analytical approaches fell short because of challenges and incompati...

Full description

Saved in:
Bibliographic Details
Published inOrganic process research & development Vol. 25; no. 8; pp. 1937 - 1942
Main Authors Zompa, Michael A, Di Maso, Michael J, Guzman, Francisco, Zhao, Ralph, Jellett, Lisa, Arvary, Rebecca, Song, Siqing, Chang, Darryl, Ren, Hong, Lohani, Sachin
Format Journal Article
LanguageEnglish
Published American Chemical Society 20.08.2021
Subjects
electrochemical detection
cyanide
control strategy
safety
chloroacetonitrile
ion chromatography
Online AccessGet full text

Cover

More Information
Summary:The manufacturing route toward gefapixant citrate generates a trace amount of cyanide as a byproduct of a reaction employing the reagent chloroacetonitrile. In the development of a cyanide control strategy, conventional process and analytical approaches fell short because of challenges and incompatibilities with the matrices of the process and waste streams. To overcome these, we identified and adapted specific procedures for cyanide control. Our strategy ensured safety for patients, operators, and waste management.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.1c00185