Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5‑Bromo-2-nitropyridine

• Published in: Organic process research & development Vol. 21; no. 3; pp. 451 - 459
• Main Authors: Agosti, Alessandro, Bertolini, Giorgio, Bruno, Giacomo, Lautz, Christian, Glarner, Thomas, Deichtmann, Walter
• Format: Journal Article
• Language: English
• Published: American Chemical Society 17.03.2017
• Subjects: process safety; ARC; nitro-aromatic; hydrogen peroxide; oxidation; thermal stability; RC1 calorimetry

5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. This transformation initially showed low conversion, high impurity content and lack of reproducibility in lab trials. Parallel to process development, safety studies were cond...