Anion Metathesis of Diaryliodonium Tosylate Salts with a Solid-Phase Column Constructed from Readily Available Laboratory Consumables

• Published in: Organic process research & development Vol. 23; no. 6; pp. 1269 - 1274
• Main Authors: Gallagher, Rory T, Seidl, Thomas L, Bader, Joshua, Orella, Charles, Vickery, Thomas, Stuart, David R
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 21.06.2019; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Applied; Chemistry, Organic; Physical Sciences; Science & Technology; anion exchange; solid-phase; diaryliodonium; arylation; MILD SYNTHESIS; ACID; ONE-POT SYNTHESIS; SCOPE; ARENES; IODINE; EXCHANGE

Herein, we describe the discovery and development of a method to exchange the counteranion component of diaryliodonium salts, which is a critical step for their use in chemical synthesis. The method involves a reusable and readily available solid-phase column assembled from common laboratory consuma...