Copper-Catalyzed Enantioselective O,S‑Rearrangement of Propargylic Xanthates: Efficient Synthesis of Chiral Propargylic Sulfur Compounds

• Published in: ACS catalysis Vol. 14; no. 17; pp. 13283 - 13290
• Main Authors: Wang, Cheng, Xiao, Mengdie, Li, Wei, Cheng, Li-Jie
• Format: Journal Article
• Language: English
• Published: American Chemical Society 06.09.2024
• Subjects: copper catalysis; base-free; chiral organosulfur compounds; O,S-rearrangement; enantioselective

A base-free, copper-catalyzed enantioselective O,S-rearrangement of propargylic xanthates has been developed to enable efficient synthesis of chiral propargylic sulfur compounds in high yields with good enantioselectivities. This method allows for the use of a variety of propargylic xanthates contai...