Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily: A Randomized Controlled Trial

• Published in: JAMA : the journal of the American Medical Association Vol. 296; no. 1; pp. 87 - 93
• Main Authors: Watkins, Paul B, Kaplowitz, Neil, Slattery, John T, Colonese, Connie R, Colucci, Salvatore V, Stewart, Paul W, Harris, Stephen C
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 05.07.2006
• Subjects: Acetaminophen - administration & dosage; Acetaminophen - pharmacokinetics; Acetaminophen - therapeutic use; Adult; Alanine Transaminase - blood; Analgesics; Analgesics, Non-Narcotic - administration & dosage; Analgesics, Non-Narcotic - pharmacokinetics; Analgesics, Non-Narcotic - therapeutic use; Analgesics, Opioid - therapeutic use; Blood tests; Drug therapy; Female; Humans; Liver diseases; Longitudinal Studies; Male; Narcotics; Placebo effect; Single-Blind Method

CONTEXT During a clinical trial of a novel hydrocodone/acetaminophen combination, a high incidence of serum alanine aminotransferase (ALT) elevations was observed. OBJECTIVE To characterize the incidence and magnitude of ALT elevations in healthy participants receiving 4 g of acetaminophen daily, ei...