Increased Expression and Amplification of blaKPC-2 Contributes to Resistance to Ceftazidime/Avibactam in a Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Strain

• Published in: Microbiology spectrum Vol. 10; no. 4; p. e0095522
• Main Authors: Li, Xinhui, Zhang, Jisheng, Yang, Chengru, Li, Jie, Wang, Jianmin, Huang, Wan, Zeng, Lingyi, Liang, Xushan, Long, Wenzhang, Zhang, Xiaoli
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 28.07.2022
• Subjects: Antimicrobial Chemotherapy; blaKPC-2; carbapenem-resistant Klebsiella pneumoniae; ceftazidime-avibactam resistance; IS26; Research Article; ceftazidime-avibactam resistance; blaKPC-2; IS26; carbapenem-resistant Klebsiella pneumoniae

Ceftazidime/avibactam (CAZ/AVI) is regarded as an effective alternative antibiotic for the clinical treatment of Klebsiella pneumoniae carbapenemase (KPC)-producing isolates. As resistance has been reported in some strains, it is critical to understand the key mechanisms contributing to the acquired...