Effect of Polyamorphism on the Morphology, Dissolution, and Stability of Olaparib

Olaparib (OLA) is an insoluble targeting antitumor drug for the treatment of ovarian cancer. Herein, polyamorphism of OLA was systematically studied aiming to improve its solubility and dissolution properties. Three amorphous forms of OLA were prepared by ball milling (form I), rotary evaporation (f...

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Bibliographic Details
Published inCrystal growth & design Vol. 24; no. 12; pp. 4906 - 4913
Main Authors Gao, Lu, Dai, Xia-Lin, Li, Shun-Yu, Vasilev, Nikita A., Perlovich, German L., Lu, Tong-Bu, Chen, Jia-Mei
Format Journal Article
LanguageEnglish
Published American Chemical Society 19.06.2024
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