Solubility and Permeability Improvement of Allopurinol by Cocrystallization

• Published in: Crystal growth & design Vol. 20; no. 8; pp. 5160 - 5168
• Main Authors: Dai, Xia-Lin, Yao, Jia, Wu, Chao, Deng, Jun-Hui, Mo, Yong-Hui, Lu, Tong-Bu, Chen, Jia-Mei
• Format: Journal Article
• Language: English
• Published: American Chemical Society 05.08.2020

Allopurinol is a xanthine oxidase inhibitor with poor solubility and permeability, which severely limit its drug absorption following the administration of some dosage forms, such as tablets and rectal suppositories. To improve the physicochemical properties, three cocrystals of allopurinol with iso...