Prostaglandin E2-Induced Immune Suppression via Cytotoxic T-Lymphocyte Antigen 4 in Paratuberculosis

• Published in: Infection and immunity Vol. 90; no. 10; p. e0021022
• Main Authors: Sajiki, Yamato, Konnai, Satoru, Watari, Kei, Okagawa, Tomohiro, Tanaka, Akina, Kawaji, Satoko, Nagata, Reiko, Maekawa, Naoya, Suzuki, Yasuhiko, Kato, Yukinari, Murata, Shiro, Mori, Yasuyuki, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 20.10.2022
• Subjects: Immunology; Microbial Immunity and Vaccines; EP4; PGE2; CTLA-4; cattle; Johne’s disease

Paratuberculosis is a chronic enteritis of ruminants caused by the facultative intracellular pathogen Mycobacterium avium subsp. paratuberculosis. The Th1 response inhibits the proliferation of M. avium subsp. paratuberculosis during the early subclinical stage. However, we have previously shown tha...