北海道のドブネズミにおけるハンタウイルス感染の流行病学的研究 : 血清疫学的調査とハンタウイルス分離株の抗原性の解析による持続感染の証拠
ドブネズミにおけるハンタウイルス感染の流行病学的研究を, 北海道内の1ごみ埋め立て処分場に棲息する感染ドブネズミ集団を対象に実施した. 1983年から1988年まで本処分場で合計11回の調査を継続し, 合計279例のドブネズミを捕獲し, 血清を得た. 抗体陽性例(IFA抗体価1:32倍以上)はいずれの調査時にも得られ, 陽性例は6ヵ月齢以上の成熟例では128例中94例(73.4%)で, 幼若例での151例中23例(15.2%)に比べ有意に高い, 明瞭な年齢依存性の感染が確認された, 抗体陽性ドブネズミの肺組織から1983年には1株(KI-83-262), 1985年には2株(KI-85-1,...
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| Published in | Journal of Veterinary Medical Science Vol. 56; no. 1; pp. 27 - 32 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
公益社団法人 日本獣医学会
1994
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| Online Access | Get full text |
| ISSN | 0916-7250 1347-7439 |
| DOI | 10.1292/jvms.56.27 |
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| Abstract | ドブネズミにおけるハンタウイルス感染の流行病学的研究を, 北海道内の1ごみ埋め立て処分場に棲息する感染ドブネズミ集団を対象に実施した. 1983年から1988年まで本処分場で合計11回の調査を継続し, 合計279例のドブネズミを捕獲し, 血清を得た. 抗体陽性例(IFA抗体価1:32倍以上)はいずれの調査時にも得られ, 陽性例は6ヵ月齢以上の成熟例では128例中94例(73.4%)で, 幼若例での151例中23例(15.2%)に比べ有意に高い, 明瞭な年齢依存性の感染が確認された, 抗体陽性ドブネズミの肺組織から1983年には1株(KI-83-262), 1985年には2株(KI-85-1, -2), 1988年には4株(KI-88-4, -11, -15, -24)のハンタウイルスが分離された. 分離ウイルスの感染性は, ウイルス分離例から得られた血清によってin vitroの試験で中和されるにもかかわらず, それらの抗原性は, 分離年次にかかわらず免疫血清や単クローン性抗体を用いたIFA法では全く, また中和試験でもわずかしか変化は認められなかった. 以上の成績からハンタウイルスはドブネズミ中で抗原性を変化させずに持続感染していることが明らかになった. |
|---|---|
| AbstractList | ドブネズミにおけるハンタウイルス感染の流行病学的研究を, 北海道内の1ごみ埋め立て処分場に棲息する感染ドブネズミ集団を対象に実施した. 1983年から1988年まで本処分場で合計11回の調査を継続し, 合計279例のドブネズミを捕獲し, 血清を得た. 抗体陽性例(IFA抗体価1:32倍以上)はいずれの調査時にも得られ, 陽性例は6ヵ月齢以上の成熟例では128例中94例(73.4%)で, 幼若例での151例中23例(15.2%)に比べ有意に高い, 明瞭な年齢依存性の感染が確認された, 抗体陽性ドブネズミの肺組織から1983年には1株(KI-83-262), 1985年には2株(KI-85-1, -2), 1988年には4株(KI-88-4, -11, -15, -24)のハンタウイルスが分離された. 分離ウイルスの感染性は, ウイルス分離例から得られた血清によってin vitroの試験で中和されるにもかかわらず, それらの抗原性は, 分離年次にかかわらず免疫血清や単クローン性抗体を用いたIFA法では全く, また中和試験でもわずかしか変化は認められなかった. 以上の成績からハンタウイルスはドブネズミ中で抗原性を変化させずに持続感染していることが明らかになった. |
| Author | 橋本, 信夫 有川, 二郎 姚, 健勝 苅和, 宏明 高島, 郁夫 伊藤, 美樹子 |
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| References | 25. Yabe, T. 1979. Eye lens weight as an age indicator in the Norway rat. J. Mammalog. Soc. Jpn. 8: 54-55. 6. Childs, J. E., Korch, G. W., Glass, G. E., LeDuc, J. W., and Shah, K. V. 1987. Epidemiology of Hantavirus infection in Baltimore: Isolation of virus from Norway rats, and characteristics of infected rat population. Am. J. Epidemiol. 126: 55-68. 13. Lee, H. W., Lee, P. W., and Johnson, K. M. 1978. Isolation of the etiologic agent of Korean hemorrhagic fever. J. Infect. Dis. 137: 298-308. 5. Calisher, C. H. 1990. Editor's comments. Arch. Virol. (Suppl. 1): 1-3. 24. World Health Organization 1983. Hemorrhagic fever with renal syndrome: memorandum from a WHO meeting. Bull WHO 61: 269-275. 22. Tanishita, O., Takahashi, Y., Okuno, Y., Tamura, M., Asada, H., Dantas, J. R. Jr., Yamanouchi, T., Domae, K., Kurata, T., and Yamanishi, K. 1986. Persistent infection of rats with hemorrhagic fever with renal syndrome virus and their antibody responses. J. Gen. Virol. 67: 2819-2824. 8. Kim, G. R. and McKee, K. T. Jr. 1985. Pathogenesis of Hantaan virus infection in suckling mice: clinical, virologic, and serologic observations. Am. J. Trop. Med. Hyg. 34: 388-395. 18. Nakamura, T., Yanagihara, R., Gibbs, C. J. Jr., Amyx, H. L., and Gajdusek, D. C. 1985. Differential susceptibility and resistant immunocompetent and immunodeficient mice to fatal Hantaan virus infection. Arch. Virol. 86: 109-120. 15. Lee, P. W., Amyx, H. L., Yanagihara, R., Gajdusek, D. C., Goldgaber, D., and Gibbs, C. J. Jr. 1985. Partial characterization of Prospect Hill virus isolated frommeadow voles in the United States. J. Infect. Dis. 152: 826-829. 20. Suzuki, S., Shimamura, H., Nagasawa, R., Takigiku, I., Tamura, T., Shoji, K., Hotta, H., Shinka, S., Kurata, T., Aoyama, Y., Yoshida, T. H., and Lee, H. W. 1984. Measurement of anti-Hantaan virus antibody, detection of endoparasites, and karyotype analysis of wild rodents captured in horbor area and in vessels at port Shimizu, Japan, 1981-1984. ICMR Annals 4: 125-141. 23. Tanishita, O., Takahashi, Y., Okuno, Y., Yamanishi, K., and Takahashi, M. 1984. Evaluation of focus reduction neutralization test with peroxidase-antiperoxidase staining technique for hemorrhagic fever with renal syndrome virus. J. Clin. Microbiol. 20: 1213-1215. 27. Yanagihara, R. and Gajdusek, C. D. 1987. Hemorrhagic fever with renal syndrome: Global epidemiology and ecology of hantavirus infections. Med. Virol. 6: 198-202. 1. Arikawa, J., Takashima, I., Morita, C., Sugiyama, K., Matsuura, Y., Shiga, S., and Kitamura, T. 1985. Epidemiological study of hemorrhagic fever with renal syndrome related virus infection among urban rats in two islands in Tokyo bay, Japan. Acta Virol. 29: 66-72. 9. Kitamura, T., Morita, C., Komatsu, T., Sugiyama, K., Arikawa, J., Shiga, S., Takeda, H., Akao, Y., Imaizumi, K., Oya, A., Hashimoto, N., and Urasawa, S. 1983. Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Jpn. J. Med. Sci. Biol. 36: 17-25. 30. Yanagihara, R., Goldgaber, D., Lee, P. W., Amyx, H. L., Gajdusek, C. D., Gibbs, C. J. Jr., and Svedmyr, A. 1984. Propagation of nephropathia epidemica virus in cell culture. Lancet i: 1013. 19. Schmaljohn, C. S., Hasty, S. E., Harrison, S. A., and Dalrymple, J. M. 1983. Characterization of Hantaan virion, the prototype virus of hemorrhagic fever with renal syndrome. J. Infect. Dis. 148: 1005-1012. 17. Morita, C., Sugiyama, Y., Matsuura, Y., Kitamura, T., Komatsu, T., Akao, Y., Jitsukawa, W., and Sakakibara, H. 1983. Detection of antibody against hemorrhagic fever with renal syndrome (HFRS) virus in sera of house rats captured in port areas of Japan. Jpn. J. Med. Sci. Biol. 36: P 55-57. 26. Yamanishi, K. and Kondo, K. 1988. Hemorrhagic fever with renal syndrome virus. Immunopharmacology & Therapy 6: 157-160 (in Japanese). 7. Chumakov, M. P., Gavrilovskaya, I. N., and Myasnikov, Y. A. 1991. Reservoirs and modes of spread of hemorrhagic fever with renal syndrome, a zoonotic nontransmissible human disease. Arch. Virol. (Suppl. 1): 49-56. 2. Arikawa, J., Takashima, I., Hashimoto, N., Takahashi, K., Yagi K., and Hattori, K. 1986. Epidemiological studies of hemorrhagic fever with renal syndrome (HFRS) related virus infection among urban rats in Hokkaido, Japan. Arch. Virol. 88: 231-240. 4. Buchmeier, M. J., Welsh, R. M., Dutko, F. J., and Oldstone, B. A. 1980. The virology andimmunobiology of lymphocytic choriomeningitis virus infection. Adv. Immunol. 30: 275-331. 21. Tamura, M., Asada, H., Kondo, K., Tanishita, O., Kurata, T., and Yamanishi, K. 1989. Pathogenesis of Hantaan virus in mice. J. Gen. Virol. 70: 2897-2906. 31. Zhang, X. K., Takashima, I., and Hashimoto, N. 1988. Role of maternal antibody in protection from hemorrhagicfever with renal syndrome virus infection in rats. Arch. Virol. 103: 253-265. 16. Morita, C., Matsuura, Y., Morikawa, Sh., and Kitamura, T. 1985. Age-dependent transmission of hemorrhagic fever with renal syndrome (HFRS) virus in rats. Arch. Virol. 85: 145-149. 10. LeDuc, J. W., Smith, G. A., and Johnson, K. M. 1984. Hantaan-like viruses from domestic rats captured in the United States. Am. J. Trop. Med. Hyg. 33: 992-998. 12. Lee, H. W., French, G. R., Lee, P. W., Baek, L. J., Tsuchiya, K., and Foulke, R. S. 1981. Observation of natural and laboratory infection of rodents with the etiologic agent of Korean hemorrhagic fever. Am. J. Trop. Med. Hyg. 30: 477-482. 11. Lee, H. W., Baek, L. J., and Johnson, K. M. 1982. Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. J. Infect. Dis. 146: 638-644. 3. Arikawa, J., Schmaljohn, A. L., Dalrymple, J. M., and Schmaljohn, C. S. 1989. Characterization of Hantaan virus envelope protein glycoprotein antigenic determinants defined by monoclonal antibodies. J. Gen. Virol. 70: 615-624. 28. Yanagihara, R., Amyx, H. L., and Gajdusek, C. D. 1985. Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus). J. Infect. Dis. 55: 34-38. 14. Lee, P. W., Amyx, H. L., Gibbs, C. J. Jr., Gajdusek, C. D., and Lee, H. W. 1981. Propagation of Korean hemorrhagic fever virus in laboratory rats. Infect. Immun. 31: 334-338. 29. Yanagihara, R., Svedmyr, A., Amyx, H. L., Lee, P. W., Goldgaber, D., Gajdusek, C. D., Gibbs, C. J. Jr., and Nystrom, K. 1984. Isolation and propagation of nephropathia epidemica virus in bank voles. Scand. J. Infect. Dis. 16: 226-228. |
| References_xml | – reference: 6. Childs, J. E., Korch, G. W., Glass, G. E., LeDuc, J. W., and Shah, K. V. 1987. Epidemiology of Hantavirus infection in Baltimore: Isolation of virus from Norway rats, and characteristics of infected rat population. Am. J. Epidemiol. 126: 55-68. – reference: 14. Lee, P. W., Amyx, H. L., Gibbs, C. J. Jr., Gajdusek, C. D., and Lee, H. W. 1981. Propagation of Korean hemorrhagic fever virus in laboratory rats. Infect. Immun. 31: 334-338. – reference: 24. World Health Organization 1983. Hemorrhagic fever with renal syndrome: memorandum from a WHO meeting. Bull WHO 61: 269-275. – reference: 27. Yanagihara, R. and Gajdusek, C. D. 1987. Hemorrhagic fever with renal syndrome: Global epidemiology and ecology of hantavirus infections. Med. Virol. 6: 198-202. – reference: 20. Suzuki, S., Shimamura, H., Nagasawa, R., Takigiku, I., Tamura, T., Shoji, K., Hotta, H., Shinka, S., Kurata, T., Aoyama, Y., Yoshida, T. H., and Lee, H. W. 1984. Measurement of anti-Hantaan virus antibody, detection of endoparasites, and karyotype analysis of wild rodents captured in horbor area and in vessels at port Shimizu, Japan, 1981-1984. ICMR Annals 4: 125-141. – reference: 23. Tanishita, O., Takahashi, Y., Okuno, Y., Yamanishi, K., and Takahashi, M. 1984. Evaluation of focus reduction neutralization test with peroxidase-antiperoxidase staining technique for hemorrhagic fever with renal syndrome virus. J. Clin. Microbiol. 20: 1213-1215. – reference: 31. Zhang, X. K., Takashima, I., and Hashimoto, N. 1988. Role of maternal antibody in protection from hemorrhagicfever with renal syndrome virus infection in rats. Arch. Virol. 103: 253-265. – reference: 9. Kitamura, T., Morita, C., Komatsu, T., Sugiyama, K., Arikawa, J., Shiga, S., Takeda, H., Akao, Y., Imaizumi, K., Oya, A., Hashimoto, N., and Urasawa, S. 1983. Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Jpn. J. Med. Sci. Biol. 36: 17-25. – reference: 18. Nakamura, T., Yanagihara, R., Gibbs, C. J. Jr., Amyx, H. L., and Gajdusek, D. C. 1985. Differential susceptibility and resistant immunocompetent and immunodeficient mice to fatal Hantaan virus infection. Arch. Virol. 86: 109-120. – reference: 8. Kim, G. R. and McKee, K. T. Jr. 1985. Pathogenesis of Hantaan virus infection in suckling mice: clinical, virologic, and serologic observations. Am. J. Trop. Med. Hyg. 34: 388-395. – reference: 5. Calisher, C. H. 1990. Editor's comments. Arch. Virol. (Suppl. 1): 1-3. – reference: 13. Lee, H. W., Lee, P. W., and Johnson, K. M. 1978. Isolation of the etiologic agent of Korean hemorrhagic fever. J. Infect. Dis. 137: 298-308. – reference: 15. Lee, P. W., Amyx, H. L., Yanagihara, R., Gajdusek, D. C., Goldgaber, D., and Gibbs, C. J. Jr. 1985. Partial characterization of Prospect Hill virus isolated frommeadow voles in the United States. J. Infect. Dis. 152: 826-829. – reference: 29. Yanagihara, R., Svedmyr, A., Amyx, H. L., Lee, P. W., Goldgaber, D., Gajdusek, C. D., Gibbs, C. J. Jr., and Nystrom, K. 1984. Isolation and propagation of nephropathia epidemica virus in bank voles. Scand. J. Infect. Dis. 16: 226-228. – reference: 17. Morita, C., Sugiyama, Y., Matsuura, Y., Kitamura, T., Komatsu, T., Akao, Y., Jitsukawa, W., and Sakakibara, H. 1983. Detection of antibody against hemorrhagic fever with renal syndrome (HFRS) virus in sera of house rats captured in port areas of Japan. Jpn. J. Med. Sci. Biol. 36: P 55-57. – reference: 12. Lee, H. W., French, G. R., Lee, P. W., Baek, L. J., Tsuchiya, K., and Foulke, R. S. 1981. Observation of natural and laboratory infection of rodents with the etiologic agent of Korean hemorrhagic fever. Am. J. Trop. Med. Hyg. 30: 477-482. – reference: 28. Yanagihara, R., Amyx, H. L., and Gajdusek, C. D. 1985. Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus). J. Infect. Dis. 55: 34-38. – reference: 26. Yamanishi, K. and Kondo, K. 1988. Hemorrhagic fever with renal syndrome virus. Immunopharmacology & Therapy 6: 157-160 (in Japanese). – reference: 4. Buchmeier, M. J., Welsh, R. M., Dutko, F. J., and Oldstone, B. A. 1980. The virology andimmunobiology of lymphocytic choriomeningitis virus infection. Adv. Immunol. 30: 275-331. – reference: 1. Arikawa, J., Takashima, I., Morita, C., Sugiyama, K., Matsuura, Y., Shiga, S., and Kitamura, T. 1985. Epidemiological study of hemorrhagic fever with renal syndrome related virus infection among urban rats in two islands in Tokyo bay, Japan. Acta Virol. 29: 66-72. – reference: 3. Arikawa, J., Schmaljohn, A. L., Dalrymple, J. M., and Schmaljohn, C. S. 1989. Characterization of Hantaan virus envelope protein glycoprotein antigenic determinants defined by monoclonal antibodies. J. Gen. Virol. 70: 615-624. – reference: 11. Lee, H. W., Baek, L. J., and Johnson, K. M. 1982. Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. J. Infect. Dis. 146: 638-644. – reference: 7. Chumakov, M. P., Gavrilovskaya, I. N., and Myasnikov, Y. A. 1991. Reservoirs and modes of spread of hemorrhagic fever with renal syndrome, a zoonotic nontransmissible human disease. Arch. Virol. (Suppl. 1): 49-56. – reference: 22. Tanishita, O., Takahashi, Y., Okuno, Y., Tamura, M., Asada, H., Dantas, J. R. Jr., Yamanouchi, T., Domae, K., Kurata, T., and Yamanishi, K. 1986. Persistent infection of rats with hemorrhagic fever with renal syndrome virus and their antibody responses. J. Gen. Virol. 67: 2819-2824. – reference: 30. Yanagihara, R., Goldgaber, D., Lee, P. W., Amyx, H. L., Gajdusek, C. D., Gibbs, C. J. Jr., and Svedmyr, A. 1984. Propagation of nephropathia epidemica virus in cell culture. Lancet i: 1013. – reference: 25. Yabe, T. 1979. Eye lens weight as an age indicator in the Norway rat. J. Mammalog. Soc. Jpn. 8: 54-55. – reference: 10. LeDuc, J. W., Smith, G. A., and Johnson, K. M. 1984. Hantaan-like viruses from domestic rats captured in the United States. Am. J. Trop. Med. Hyg. 33: 992-998. – reference: 16. Morita, C., Matsuura, Y., Morikawa, Sh., and Kitamura, T. 1985. Age-dependent transmission of hemorrhagic fever with renal syndrome (HFRS) virus in rats. Arch. Virol. 85: 145-149. – reference: 19. Schmaljohn, C. S., Hasty, S. E., Harrison, S. A., and Dalrymple, J. M. 1983. Characterization of Hantaan virion, the prototype virus of hemorrhagic fever with renal syndrome. J. Infect. Dis. 148: 1005-1012. – reference: 21. Tamura, M., Asada, H., Kondo, K., Tanishita, O., Kurata, T., and Yamanishi, K. 1989. Pathogenesis of Hantaan virus in mice. J. Gen. Virol. 70: 2897-2906. – reference: 2. Arikawa, J., Takashima, I., Hashimoto, N., Takahashi, K., Yagi K., and Hattori, K. 1986. Epidemiological studies of hemorrhagic fever with renal syndrome (HFRS) related virus infection among urban rats in Hokkaido, Japan. Arch. Virol. 88: 231-240. |
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| Title | 北海道のドブネズミにおけるハンタウイルス感染の流行病学的研究 : 血清疫学的調査とハンタウイルス分離株の抗原性の解析による持続感染の証拠 |
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| ispartofPNX | Journal of Veterinary Medical Science, 1994/02/15, Vol.56(1), pp.27-32 |
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