General Route toward Side-Chain-Functionalized α-Helical Polypeptides

• Published in: Biomacromolecules Vol. 11; no. 6; pp. 1585 - 1592
• Main Authors: Tang, Haoyu, Zhang, Donghui
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 14.06.2010; Amer Chemical Soc
• Subjects: Aminoacid polymers; Applied sciences; Biochemistry & Molecular Biology; Chemistry; Chemistry, Organic; Circular Dichroism; Exact sciences and technology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Mannose - chemistry; Molecular Weight; Organosilicon Compounds - chemistry; Peptides - chemical synthesis; Peptides - chemistry; Physical Sciences; Physicochemistry of polymers; Polyglutamic Acid - analogs & derivatives; Polyglutamic Acid - chemical synthesis; Polyglutamic Acid - chemistry; Polymer Science; Protein Conformation; Science & Technology; Solutions; Synthetic biopolymers; DESIGN; 1ST SYNTHESIS; GLYCOPOLYMERS; CLICK CHEMISTRY; FOLDAMERS; DYNAMICS; RING-OPENING POLYMERIZATION; COPOLYMERS; N-CARBOXYANHYDRIDES; COMBINATION; Ring opening polymerization; 1,3-Dipolar cycloaddition; Alkyl glutamate polymer; Aldose; Experimental study; Aminoacid polymer; Thermal stability; Organic solution; Glycopolymer; Azides; Solid state; Monodispersed polymer; Chemical modification; Preparation; Soluble compound; Helical structure; Chlorine containing polymer; Aqueous solution; Nucleophilic substitution; Conformation

A series of poly(γ-chloropropyl-l-glutamate) (PCPLG) with controlled polymer molecular weight (MW = 5−28 kg·mol−1) and molecular weight distribution (PDI = 1.16−1.26) have been prepared from hexamethyldisilazane (HMDS)-mediated ring-opening polymerization (ROP) of γ-chloropropyl-l-glutamic acid base...