Copper-Based Metal–Organic Framework Overcomes Cancer Chemoresistance through Systemically Disrupting Dynamically Balanced Cellular Redox Homeostasis

• Published in: Journal of the American Chemical Society Vol. 144; no. 11; pp. 4799 - 4809
• Main Authors: Liu, Jia, Yuan, Ye, Cheng, Yanni, Fu, Daan, Chen, Zhongyin, Wang, Yang, Zhang, Lifang, Yao, Chundong, Shi, Lin, Li, Mingyi, Zhou, Cheng, Zou, Meizhen, Wang, Guobin, Wang, Lin, Wang, Zheng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 23.03.2022
• Subjects: animal models; Animals; autoxidation; biocompatibility; catechol; Catechols - pharmacology; Cell Line, Tumor; coordination polymers; copper; Copper - chemistry; cytotoxicity; Drug Resistance, Neoplasm; glutathione; Glutathione - metabolism; Homeostasis; ligands; Metal-Organic Frameworks - metabolism; Metal-Organic Frameworks - pharmacology; Mice; multiple drug resistance; neoplasms; Neoplasms - drug therapy; Oxidation-Reduction; oxidative stress; therapeutics

Chemodrug resistance is a major reason accounting for tumor recurrence. Given the mechanistic complexity of chemodrug resistance, molecular inhibitors and targeting drugs often fail to eliminate drug-resistant cancer cells, and sometimes even promote chemoresistance by activating alternative pathway...