Copper-Based Metal–Organic Framework Overcomes Cancer Chemoresistance through Systemically Disrupting Dynamically Balanced Cellular Redox Homeostasis - Liu, Jia; Yuan, Ye; Cheng, Yanni; Fu, Daan; Chen, Zhongyin; Wang, Yang; Zhang, Lifang; Yao, Chundong; Shi, Lin; Li, Mingyi; Zhou, Cheng; Zou, Meizhen; et al. (Journal of the American Chemical Society, 2022)
Keywords: animal models; Animals; autoxidation; biocompatibility; catechol; Catechols - pharmacology; Cell Line, Tumor; coordination polymers; copper; Copper - chemistry; cytotoxicity; Drug Resistance, Neoplasm; glutathione; Glutathione - metabolism; Homeostasis; ligands; Metal-Organic Frameworks - metabolism; Metal-Organic Frameworks - pharmacology; Mice; multiple drug resistance; neoplasms; Neoplasms - drug therapy; Oxidation-Reduction; oxidative stress; therapeutics