Development of 68Ga-Labeled Hepatitis E Virus Nanoparticles for Targeted Drug Delivery and Diagnostics with PET

• Published in: Molecular pharmaceutics Vol. 19; no. 8; pp. 2971 - 2979
• Main Authors: Lambidis, Elisavet, Chen, Chun-Chieh, Baikoghli, Mo, Imlimthan, Surachet, Khng, You Cheng, Sarparanta, Mirkka, Cheng, R. Holland, Airaksinen, Anu J.
• Format: Journal Article
• Language: English
• Published: American Chemical Society 01.08.2022
• Subjects: DOTA; hepatotropism; gallium-68; hepatitis E viral nanoparticles; virus-like particle; positron emission tomography tracers

Targeted delivery of diagnostics and therapeutics offers essential advantages over nontargeted systemic delivery. These include the reduction of toxicity, the ability to reach sites beyond biological barriers, and the delivery of higher cargo concentrations to diseased sites. Virus-like particles (V...