An Updated Simple SN2 Reaction for the Undergraduate Organic Laboratory

• Published in: Journal of chemical education Vol. 100; no. 1; pp. 376 - 379
• Main Authors: Khuong, Kelli S., Agnelli, Fabio, Parker, Matthew A.
• Format: Journal Article
• Language: English
• Published: Easton American Chemical Society and Division of Chemical Education, Inc 10.01.2023; American Chemical Society
• Subjects: Chemical reactions; Experiments; Halides; Organic chemistry; Sodium hydroxide; Toxicity; Synthesis; Laboratory Instruction; Second-Year Undergraduate; Reactions; Ethers; Thin Layer Chromatography; Alkylation; Organic Chemistry

SN2 reactions are of fundamental importance in introductory organic chemistry courses, and a number of experiments suitable for the first-semester undergraduate organic lab have been previously reported. Most of these experiments have used alkyl halides as electrophiles, but alkyl halides are often...